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Helix-grafted Proteins as Inhibitors of Disease-relevant Protein-protein Interactions
Helix Grafted Proteins Inhibition of HIV-1 InfectionInventors:Brian R McNaughtonAlan J KennanSusanne N WalkerRachel L TennysonAlex M ChapmanAt a GlanceMcNaughton et al. engineered helix-grafted scaffolds capable of inhibiting HIV infection in a live-virus assay, by disruption of gp41 (the crucial c-terminal sequence responsible for enabling fusion of...
Published: 4/4/2019
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Inventor(s): Brian Mcnaughton, Alan Kennan, Susanne Walker, Rachel Tennyson, Alex Chapman
Keywords(s):
Category(s): Human Health, Biotechnology
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Evolved proteins lead to anti-HIV cyclic peptides
Novel Peptides Bind Elusive Therapeutic Target Critical to HIV Lifecycle Inventors - Brian McNaughton and David CrawfordAt a Glance McNaughton and Crawford have developed cyclic peptides with high affinity binding to the HIV-1 Trans-activation response (TAR) element RNA - a validated drug target comprising conserved, bulged stem-loop structures...
Published: 4/4/2019
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Inventor(s): Brian Mcnaughton, David Crawford
Keywords(s):
Category(s): Biotechnology, Human Health
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Nanobody conjugates and protein fusions as bioanalytical reagents
In many bioanalytical techniques, antibodies are essential for performing a technique. These antibodies recognize a particular protein (known as an epitope) and are often linked/conjugated to proteins or dyes to allow visualization (known as reporters). The size and complexity of traditional antibodies and the reporter conjugates complicates their...
Published: 4/4/2019
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Inventor(s): Brian Mcnaughton, Virginia (Ginny) Bruce
Keywords(s):
Category(s): Biotechnology
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Split-Supercharged GFP: A Robust Platform to Detect Protein-Protein Interactions
Patent Status: US Patent Issued, PCT Patent PendingFeatures and Benefits• Rapid detection of polypeptide interactions inside E. coli• High signal-to-noise• Efficient peptide-peptide interaction detection at physiological temperature• Detection of interactions involving aggregation-prone polypeptides Split-supercharged...
Published: 11/8/2018
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Inventor(s): Brian Mcnaughton, Brett Blakeley, Alex Chapman
Keywords(s):
Category(s): Biotechnology, Chemicals & Materials, Other Innovations
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Multifunctional Phage as Targeted Delivery Platforms for Therapies and Imaging Reagents
Phage that potently and selectively delivery various cargo to cancer cells, with application to many human and other mammalian cancers.Innovation DetailsEvery strategy to identify and combat disease can be improved by selective delivery of cargo specifically to diseased cells. Small molecules and nanoparticles have been used to target many diseases...
Published: 11/8/2018
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Inventor(s): Brian Mcnaughton, Sandra Deporter, Irene Lui
Keywords(s):
Category(s): Biotechnology, Human Health, Chemicals & Materials
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