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Flexible multilayered pump for use as a ventricular assist device
At a Glance: This invention is essentially a ventricular assist device, made up of a flexible polymer involving prosthetic heart valves, hydraulic chambers and an artificial muscle, which will be used to help drive blood flow and are also used during heart failure. This invention is believed to result in fewer adverse outcomes for patients, such a...
Published: 4/4/2019
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Inventor(s): David Bark
Keywords(s):
Category(s): Biotechnology, Chemicals & Materials, Human Health
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Helix-grafted Proteins as Inhibitors of Disease-relevant Protein-protein Interactions
Helix Grafted Proteins Inhibition of HIV-1 InfectionInventors:Brian R McNaughtonAlan J KennanSusanne N WalkerRachel L TennysonAlex M ChapmanAt a GlanceMcNaughton et al. engineered helix-grafted scaffolds capable of inhibiting HIV infection in a live-virus assay, by disruption of gp41 (the crucial c-terminal sequence responsible for enabling fusion of...
Published: 4/4/2019
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Inventor(s): Brian Mcnaughton, Alan Kennan, Susanne Walker, Rachel Tennyson, Alex Chapman
Keywords(s):
Category(s): Human Health, Biotechnology
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Strain Sensor Device With a Biological Substrate and Method of Manufacturing Thereof
At a Glance• Metal-based device that is incorporated into bone grafts to measure strain on the graft.• Sensitive strain measurements must be taken to ensure functionality of bone allografts, which are increasingly being used to treat orthopedic issues.• This device can be applied to the over 200,000 bone allografts transplanted...
Published: 4/4/2019
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Inventor(s): Hilmi Volkan-Demir
Keywords(s):
Category(s): Biotechnology, Electronic Devices & Instrumentation, Human Health
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Evolved proteins lead to anti-HIV cyclic peptides
Novel Peptides Bind Elusive Therapeutic Target Critical to HIV Lifecycle Inventors - Brian McNaughton and David CrawfordAt a Glance McNaughton and Crawford have developed cyclic peptides with high affinity binding to the HIV-1 Trans-activation response (TAR) element RNA - a validated drug target comprising conserved, bulged stem-loop structures...
Published: 4/4/2019
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Inventor(s): Brian Mcnaughton, David Crawford
Keywords(s):
Category(s): Biotechnology, Human Health
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Slotted Waveguide Array RF Coil for Ultra-High-Field MRI
Slotted Waveguide Array RF Coil for Ultra-High-Field MRIProblem to be Solved:Current magnetic resonance imaging (MRI) technology utilizes a relatively low static magnetic field (B0 ≤ 3T). Ultra-high field (B0 ≥ 7) imagers increase sensitivity and functionality of MRI overall, but come with their own set of challenges. At higher magnetic fields,...
Published: 4/4/2019
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Inventor(s): Branislav Notaros, Milan Ilic
Keywords(s):
Category(s): Electronic Devices & Instrumentation, Communications & Signal Processing, Human Health, Other Innovations
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HeX-Bond for molecular engineering, medicinal chemistry applications, materials chemistry, and biological or chemical engineering
Investigators at Colorado State University have discovered a new form of a non-covalent interaction, which is named a hydrogen bond enhanced halogen bond (or HeX-B, for short). The HeX-B was engineered into the enzyme lysozyme to increase the thermal stability of a commonly used enzyme by 1°C and the activity by 15% at elevated temperatures relative...
Published: 4/4/2019
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Inventor(s): Pui Shing Ho, Anna-Carin Carlsson, Matthew Scholfield, Melissa Ford, Rhianon Rowe Hartje, Austin Alexander, Ryan Mehl
Keywords(s):
Category(s): Biotechnology, Chemicals & Materials, Human Health
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Methods for Coating Bone Allografts with Periosteum-Mimetic Tissue Engineering Scaffolds
The inability of bone to heal large defects necessitates the use of bone grafts in many traumatic injuries and disease states. Autograft bone exhibits superior healing over other options due to its inherent ability to provide an osteoconductive scaffold, osteoinductive growth factors, and autogenous osteogenic cells. Unfortunately, limited donor site...
Published: 4/4/2019
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Inventor(s): Matthew Kipper, Nicole Ehrhart, Raimundo Romero, Timothy Gonzales
Keywords(s):
Category(s): Biotechnology, Chemicals & Materials, Human Health
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Industrial Hygiene Personal Sampling Belt
Industrial hygiene, also known as occupational hygiene, involves the anticipation, recognition, evaluation, control and prevention of hazards from work activities that may result in injury, illness, or otherwise affect the well being of workers. Industrial hygiene is thus both preventative and occupational in nature, being that the focus is on preventing...
Published: 4/4/2019
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Inventor(s): William Brazile, Mollie Brazile
Keywords(s):
Category(s): Human Health, Electronic Devices & Instrumentation, Other Innovations
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Bio-Inspired Siloxane Materials for Ocular Applications
It is estimated that there are over 30 million contact lens wearers in the United States.
In addition to vision correction, a contact lens should:
Maintain stable, continuous tear film for clear vision
Resist deposition of tear film components
Sustain normal hydration
Permeable to oxygen enabling corneal metabolism
Permeable to ions to maintain...
Published: 4/4/2019
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Inventor(s): Susan James, Travis Bailey, Ketul Popat
Keywords(s):
Category(s): Human Health
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Biocompatible Coatings for Heart Valves and Vascular Grafts
There are currently 300,000 heart valve replacements each year worldwide and this number is estimated to triple by 20501. The materials most often utilized for these replacement valves can have substantial drawbacks for patient health. Bioprosthetic heart valves have shorter functional lifespans when compared to non-biological mechanical heart valves...
Published: 4/4/2019
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Inventor(s): Susan James, Harold Dean iv, Lakshmi Prasad Dasi, Marcio Forleo
Keywords(s):
Category(s): Human Health
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