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Nickel-Catalyzed C-N Cross-Coupling via Direct Photoexcitation of Nickel-Amine Complexes
Mild Nickel-Catalyzing Cross-Coupling MethodologyC-N Cross-Coupling via Photoexcitation of Nickel-Amine Complexes At a GlanceWe introduce a carbon-nitrogen (C-N) cross-coupling method that operates at room temperature using an inexpensive nickel (Ni) source while being tolerant to oxygen and proceeds through direct irradiation of the Ni complex...
Published: 5/30/2019
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Inventor(s): Garret Miyake, Chern-Hooi Lim, Max Kudisch, Bin Liu
Keywords(s):
Category(s): Chemicals & Materials, Biotechnology
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Flexible multilayered pump for use as a ventricular assist device
At a Glance: This invention is essentially a ventricular assist device, made up of a flexible polymer involving prosthetic heart valves, hydraulic chambers and an artificial muscle, which will be used to help drive blood flow and are also used during heart failure. This invention is believed to result in fewer adverse outcomes for patients, such a...
Published: 4/4/2019
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Inventor(s): David Bark
Keywords(s):
Category(s): Biotechnology, Chemicals & Materials, Human Health
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Helix-grafted Proteins as Inhibitors of Disease-relevant Protein-protein Interactions
Helix Grafted Proteins Inhibition of HIV-1 InfectionInventors:Brian R McNaughtonAlan J KennanSusanne N WalkerRachel L TennysonAlex M ChapmanAt a GlanceMcNaughton et al. engineered helix-grafted scaffolds capable of inhibiting HIV infection in a live-virus assay, by disruption of gp41 (the crucial c-terminal sequence responsible for enabling fusion of...
Published: 4/4/2019
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Inventor(s): Brian Mcnaughton, Alan Kennan, Susanne Walker, Rachel Tennyson, Alex Chapman
Keywords(s):
Category(s): Human Health, Biotechnology
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Strain Sensor Device With a Biological Substrate and Method of Manufacturing Thereof
At a Glance• Metal-based device that is incorporated into bone grafts to measure strain on the graft.• Sensitive strain measurements must be taken to ensure functionality of bone allografts, which are increasingly being used to treat orthopedic issues.• This device can be applied to the over 200,000 bone allografts transplanted...
Published: 4/4/2019
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Inventor(s): Hilmi Volkan-Demir
Keywords(s):
Category(s): Biotechnology, Electronic Devices & Instrumentation, Human Health
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Evolved proteins lead to anti-HIV cyclic peptides
Novel Peptides Bind Elusive Therapeutic Target Critical to HIV Lifecycle Inventors - Brian McNaughton and David CrawfordAt a Glance McNaughton and Crawford have developed cyclic peptides with high affinity binding to the HIV-1 Trans-activation response (TAR) element RNA - a validated drug target comprising conserved, bulged stem-loop structures...
Published: 4/4/2019
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Inventor(s): Brian Mcnaughton, David Crawford
Keywords(s):
Category(s): Biotechnology, Human Health
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A Metal Reducing Enzymatic Tag for Optical and Electron Microscopy
At a Glance: ● A clonable maker for electron and optical microscopy. ● Allows for high resolution imaging using non-disruptive modalities● Can be readily adapted to flow cytometry● Potential to provide a platform for radio frequency interactions with a protein of interest.● Immediately applicable markets: academic research,...
Published: 4/4/2019
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Inventor(s): Christopher Ackerson, Zachary Butz, Richard Nemeth, Ryan Riskowski, Kanda Borgognoni
Keywords(s):
Category(s): Biotechnology, Chemicals & Materials, Electronic Devices & Instrumentation
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HeX-Bond for molecular engineering, medicinal chemistry applications, materials chemistry, and biological or chemical engineering
Investigators at Colorado State University have discovered a new form of a non-covalent interaction, which is named a hydrogen bond enhanced halogen bond (or HeX-B, for short). The HeX-B was engineered into the enzyme lysozyme to increase the thermal stability of a commonly used enzyme by 1°C and the activity by 15% at elevated temperatures relative...
Published: 4/4/2019
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Inventor(s): Pui Shing Ho, Anna-Carin Carlsson, Matthew Scholfield, Melissa Ford, Rhianon Rowe Hartje, Austin Alexander, Ryan Mehl
Keywords(s):
Category(s): Biotechnology, Chemicals & Materials, Human Health
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Methods for Coating Bone Allografts with Periosteum-Mimetic Tissue Engineering Scaffolds
The inability of bone to heal large defects necessitates the use of bone grafts in many traumatic injuries and disease states. Autograft bone exhibits superior healing over other options due to its inherent ability to provide an osteoconductive scaffold, osteoinductive growth factors, and autogenous osteogenic cells. Unfortunately, limited donor site...
Published: 4/4/2019
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Inventor(s): Matthew Kipper, Nicole Ehrhart, Raimundo Romero, Timothy Gonzales
Keywords(s):
Category(s): Biotechnology, Chemicals & Materials, Human Health
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Nanobody conjugates and protein fusions as bioanalytical reagents
In many bioanalytical techniques, antibodies are essential for performing a technique. These antibodies recognize a particular protein (known as an epitope) and are often linked/conjugated to proteins or dyes to allow visualization (known as reporters). The size and complexity of traditional antibodies and the reporter conjugates complicates their...
Published: 4/4/2019
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Inventor(s): Brian Mcnaughton, Virginia (Ginny) Bruce
Keywords(s):
Category(s): Biotechnology
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Method and Apparatus for Generation of Traveling Waves in High-Field and Ultra-High-Field MRI Systems Using Bore-Extended, Subject-Loaded Helical Antennas
Summary:The main area of engineering research in advancing next-generation MRI scanners at high (B0=3T) and ultra-high (B0 > 3 T) polarizing fields is in improving RF coils and RF magnetic fields (B1) in an MRI bore loaded with a human body or a phantom. This invention features a new RF coil, the subject-loaded multi-channel helical-antenna RF...
Published: 4/4/2019
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Inventor(s): Branislav Notaros, Milan Ilic, Alexey Tonyushkin, Nada Sekeljic, Pranav Athalye
Keywords(s):
Category(s): Biotechnology, Electronic Devices & Instrumentation
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